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Tapentadol prolonged release for the management of chronic low back pain In a prospective, randomized, double blind, activeand placebo-controlled, multicentre, phase III study in 981 patients with moderate to severe chronic low back pain, tapentadol prolonged release (100–250mg twice daily) and oxycodone controlled release (20–50mg twice daily) significantly reduced mean pain intensity compared with placebo over the treatment period (3-week tapentadol with paracetamol nucynta grunenthal tapentadol morphine palexia ir 50 mg nucynta titration maintenance period)16 .
This study did not directly compare the analgesic efficacy of tapentadol prolonged release and oxycodone controlled release, but the data suggest similar efficacy and a dose equivalency of approximately 5:1 tapentadol for tapentadol prolonged release to oxycodone controlled release .
The most common treatment emergent adverse events (reported by ≥10% patients in tapentadol principio activo nucynta ir 50 mg tapentadol iupac nucynta om 50 tapentadol fentanyl any group) were nausea, constipation, headache, vomiting, dizziness, pruritus and somnolence .
The incidence of vomiting, constipation and pruritus in the tapentadol tapentadol prolonged release group was reported to be approximately half of that in the oxycodone controlled release group, and the odds of experiencing constipation or the composite of nausea and/or vomiting were significantly lower for tapentadol prolonged release compared to oxycodone controlled release .

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