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The elevated levels of cytokines and chemokines can promote and amplify diazepam the inflammatory response [2] .
These cytokines and chemokines are generally proteins, in addition to the low-molecular weight lipids diazepam derived from arachidonic acid, are playing an important proinflammatory role .
In addition to this, diazepam gases like nitric oxide and carbon monoxide are recognized also as inflammatory mediators [3] .
Experimental and clinical evidences suggested that benzodiazepines could influence immune cell diazepam properties, such as phagocyte activity, chemotaxis and the production of superoxide, and cytokines; either by reducing the stress and anxiety or through stimulation of Peripheral Benzodiazepine Receptors (PBRS) [4] .
These PBRS have been identified mainly into cheap diazepam pakistan diazepam 10 mg for seizures valium pill mg diazepam quizlet valium high the mitochondria of non-neuronal peripheral cells as adrenocortical cells [5] and also, in the cellular components of the immune system, such as monocytes, neutrophils, macrophages [6] .
Ligands of PBRs have been found to regulate activity of genes responsible for biosynthesis of cholesterol derivatives as corticosterone valium wiki diazepam 5mg effective time ic diazepam 5mg valium and ambien high valium nzxt diazepam modulate monocyte functions such as chemotaxis [7,8] .
Also, these ligands have diazepam been reported to suppress the production of IL-1, IL-2, IL-6, TNF-α, IFN-γ, and to increase glucocorticoid production [9] .
Therefore, this study aims to investigate the possible anti-inflammatory effects of the diazepam on acute and chronic inflammatory responses in the rats with exploring the possible diazepam underlying mechanisms involved in these anti-inflammatory actions .

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